Diagnosis of Wilson's disease begins with a medical history and physical exam. Usually there are high levels of copper in the urine. Often the level of a special protein in the blood is lower than normal. A liver biopsy involves taking a small piece of liver with a special needle put through the skin. The piece can then be examined under a microscope for excess copper. Other tests are also useful, for example measuring the quantity of copper passed into the urine daily (high in Wilson's disease). Another lab test measures the ability of a sample of a patient's ceruloplasmin to bind with a form of copper (decreased in Wilson's disease).
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