How is Lambert-Eaton Myasthenic syndrome diagnosed?
The doctor will perform a thorough physical examination when LEMS is suspected. The doctor will be looking for decreased muscle reflexes and muscle weakness that may transiently improve after brief exercise. The diagnosis is based on a typical history with in addition with low compound muscle action potential after nerve stimulation with decrement at low frequency stimulation (3 Hz) of more than 10%, and increment after high frequency stimulation (more than 20 Hz or preferably maximal voluntary contraction) of more than 100%, as well as presence of anti-P/Q-type voltage-gated calcium channel antibodies in the serum. The diagnosis is readily confirmed with a test called an electromyogram (EMG), a procedure that assesses nerve and muscle function. In many patients, the LEMS antibody can be identified in a simple blood test.
More information on Lambert-Eaton Myasthenic syndrome
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