health care  
 
All about prion diseases Creutzfeldt-Jakob disease types of Creutzfeldt-Jakob disease variant Creutzfeldt-Jakob disease (vCJD) causes of Creutzfeldt-Jakob disease symptoms of Creutzfeldt-Jakob disease diagnosis of Creutzfeldt-Jakob disease treatment for Creutzfeldt-Jakob disease prevention of Creutzfeldt-Jakob disease fatal familial insomnia (FFI) Kuru

Fatal familial insomnia

Fatal familial insomnia (FFI) is an hereditary prion disease characterized by disrupted sleep (insomnia), motor abnormalities (myoclonus, ataxia, dysarthria, dysphagia, and pyramidal signs), and hyperactivation of the autonomic

nervous system. Due to a missense mutation at codon 178 of the prion protein gene on chromosome 20. A sporadic form of fatal insomnia is also known.

Fatal familial insomnia is caused by prions, similar to Creutzfeldt-Jakob disease and bovine spongiform encephalopathy. The same protein implicated in Creutzfeld-Jakob disease is altered (asparagine-178 is replaced by aspartic acid), causing amyloid plaques in the thalamus, the region of the brain responsible for sleep. The dysfunction of the thalamus results in insomnia. The disease usually begins between the ages of 40 and 60 but may begin in a person's late 30s. Most often, it runs in families. At first, people may have minor difficulties falling asleep and occasional problems with muscle movements. Eventually, they lose the ability to sleep. Other changes include muscle twitching, rapid heart rate, and dementia. Death usually occurs after about 7 to 36 months of illness. No treatment is available.

More information on prion diseases (Creutzfeldt-Jakob disease, fatal familial insomnia, kuru)

What're prion diseases? - Prion diseases (transmissible spongiform encephalopathies) are a group of inherited and spontaneous neurodegenerative disorders affecting animals and humans.
What is Creutzfeldt-Jakob disease? - Creutzfeldt-Jakob disease is degenerative brain disorder. Creutzfeldt-Jakob disease (CJD) is a rapidly progressive disease causing damage to the brain.
What types of Creutzfeldt-Jakob disease are there? - There are three types of Creutzfeldt-Jakob Disease: sporadic (or classical), hereditary (or familial) and acquired (or iatrogenic).
What's variant Creutzfeldt-Jakob disease (vCJD)? - Variant Creutzfeldt-Jakob disease (vCJD) is a rare and fatal human neurodegenerative condition. vCJD affects younger patients.
What causes Creutzfeldt-Jakob disease? - There are three main causes for classic CJD. Creutzfeldt-Jakob disease through infection is transmitted by prions.
What're the symptoms of Creutzfeldt-Jakob disease? - Symptoms of Creutzfeldt-Jakob disease include forgetfulness and nervousness, jerky, trembling hand movements, unsteady gait, myoclonus.
How is Creutzfeldt-Jakob disease diagnosed? - Creutzfeldt-Jakob disease is diagnosed by a clinical neurological exam and electroencephalography (EEG).
What's the treatment for Creutzfeldt-Jakob disease? - There is no cure for Creutzfeldt-Jakob disease, and no treatment which slows the progression of the disease.
How to prevent Creutzfeldt-Jakob disease? - Creutzfeldt-Jakob disease is prevented by handling their fluids and tissues with extreme caution and by using special sterilization methods to disinfect equipment.
What is fatal familial insomnia? - Fatal familial insomnia is caused by prions, similar to Creutzfeldt-Jakob disease and bovine spongiform encephalopathy.
What is Kuru? - Kuru is a degenerative nerve disease caused by a prion (infectious protein) transmitted to humans via contaminated human brain tissue.
Neurological disorders Mainpage

Topics in neurological disorders

Autoimmune nervous system diseases
Autonomic nervous system diseases
Degenerative nervous system diseases
Central nervous system diseases
Brain diseases
Cranial nerve disorders
Headaches
Dementia
Language disorders
Perceptual disorders
Motor neuron diseases
Neurologic manifestations
Movement disorders
Peripheral nerve disorders
Sleep disorders
Spinal cord diseases
 

Featured neurological articles

Multiple sclerosis
Cerebral palsy
Migraine headache
Cluster headache
Alzheimer's disease
Stuttering
Chronic fatigue syndrome
Parkinson's disease
Carpal tunnel syndrome
Neuropathy
Peripheral neuropathy
Diabetic neuropathy
Lower back pain
Snoring
Sleep apnea
Brain tumor
Brain cancer
Spinal cord tumors

Nutrition for neurological disorders


MindSoothe for emotional health
MindSoothe, a natural herbal remedy, contains a selection of herbs known for their calming and supportive function in maintaining brain and nervous system health, emotional balance and overall wellbeing.

Neuro Natural Memory
Specifically formulated to help support brain health, Neuro-Natural Memory may help improve memory, concentration levels and reduce the potential for brain and memory function problems.

Triple Complex Sleep Tonic
Sleep Tonic helps the body relax and produce all the hormones essential for healthy sleep; safe for everyone, including pregnant and nursing women, children, and small babies.


All information is intended for reference only. Please consult your physician for accurate medical advices and treatment. Copyright 2005, health-cares.net, all rights reserved. Last update: July 18, 2005