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All about Shy-Drager syndrome causes of Shy-Drager syndrome symptoms of Shy-Drager syndrome diagnosis of Shy-Drager syndrome treatment for Shy-Drager syndrome

What causes Shy-Drager syndrome?

Shy-Drager syndrome is a rare degenerative condition. It is a condition that appears similar to Parkinson's disease in that patients may be slow moving, tremulous and have a shuffling gait but with more widespread neurologic damage and

damage to the autonomic nervous system (the portion of the nervous system that controls involuntary functions).

There is neuronal loss and gliosis in the inferior olives, pons, cerebellum, substantia nigra, locus ceruleus, striatum and the intermediolateral column of the spinal cord. Typical but not specific to MSA are argyrophilic inclusions containing accumulations of tubules. Alpha-synuclein has recently been shown to be accumulated in glial cytoplasmic incusions. Alpha synuclein is also a component of Lewy bodies in sporadic Parkinsonism, dementia with Lewy bodies, and a rare variant of Alzheimer's disease with abundant Lewy bodies. This is in distinction to the "tau" rich inclusion bodies found in most types of Alzheimer's disease and progressive supranuclear palsy. Depletion of catecholamine neurons in the rostral ventrolateral medulla is a consistant finding in patients with MSA and autonomic failure.

The cause is unknown. There is progressive damage (degeneration) of the nervous system, with damage to all parts of the nervous system. The disorder develops gradually. It is most often diagnosed in men over 60 years old.

More information on Shy-Drager syndrome

What is Shy-Drager syndrome? - Shy-Drager syndrome is a mysterious progressive disorder of the central and sympathetic nervous systems, also called multiple system atrophy with postural hypotension.
What causes Shy-Drager syndrome? - Shy-Drager syndrome is a rare degenerative condition. The cause is unknown. There is progressive damage (degeneration) of the nervous system.
What're the symptoms of Shy-Drager syndrome? - Symptoms of Shy-Drager syndrome include constipation, impotence in men, urinary incontinence, impaired speech, difficulties with breathing and swallowing, and inability to sweat (anhidrosis).
How is Shy-Drager syndrome diagnosed? - Tests of the autonomic nervous system may help diagnose Shy-Drager syndrome. Another test for the condition is the Valsalva maneuver.
What's the treatment for Shy-Drager syndrome? - There is no cure for the Shy-Drager syndrome. The treatment is aimed at controlling symptoms such as postural hypotension and parkinsonian movements.
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All information is intended for reference only. Please consult your physician for accurate medical advices and treatment. Copyright 2005,, all rights reserved. Last update: July 18, 2005